nanoFX®

nanoFX® is a medical system for the treatment of chondral and osteochondral defects, which creates direct access channels for mesenchymal stem cells through standardized 9 mm deep and 1 mm narrow perforations and thus promotes effective cartilage regeneration with a hyaline-like character.

Higher stem cell yield compared to traditional microfracturing techniques

The controlled depth of the perforations of 9 mm results in effective bone marrow stimulation, which leads to a higher yield of mesenchymal stem cells, which are crucial for cartilage regeneration.

Protecting the subchondral plate

The 1 mm narrow diameter of the access channels protects the subchondral plate and spongy tissue, which promotes rapid healing and restoration of the subchondral bone. In addition, the narrow diameter also enables a higher perforation density compared to microfracturing, which further optimizes tissue regeneration.

Easy and safe to use

The nanoFX® system is suitable for arthroscopic or minimally invasive use and requires no preoperative preparation, which makes handling easier and increases patient safety.

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Indications of nanoFX®

Chondral defects

Localized cartilage damage caused by injuries or degenerative diseases.

Osteochondral defects

damage that affects both cartilage and the underlying bone.

Degenerative joint diseases

Early stages of osteoarthritis aimed at improving cartilage quality.

Sports injuries

Acute or chronic cartilage injuries caused by sporting activities.

Post-traumatic cartilage damage

Cartilage damage that occurs after accidents or trauma.

Cartilage defects following malpositions

Cartilage damage caused by biomechanical misalignments of the joints.

Limited defects in large joints

Minor to medium-sized cartilage damage in large joints such as the knee, hip, or shoulder.

Revision after failed cartilage treatments

Use in patients who have not responded adequately to previous cartilage repair methods

SMALLER

Narrower channels for minimal tissue damage

The narrow channels reduce trauma to the subchondral bone surface & enable a higher perforation density.

Schematische Darstellung der Mikrofrakturierung: große, flache Kanäle mit geringer Stimulationstiefe und höherer Gewebestörung

Old method

microfracturing

Larger, shallower channels with less deep stimulation and more tissue disruption.

Schematische Darstellung der Nanofrakturierung mit NanoFx®: kleine, tiefe Kanäle für intensivere Stimulation, minimale Gewebestörung und erhöhte Stammzellenausbeute

New method

nanoFX® (nanofracturing)

Smaller, deeper channels with more intensive stimulation and less tissue disruption, resulting in higher stem cell yield.

DEEPER

Deeper perforation for higher stem cell yield

With the deeper performance of Nano FX®, more stem cells can be obtained:

Illustration eines Mikrofrakturierungsinstruments, das flache Kanäle mit einer Tiefe von durchschnittlich 3 mm in den Knochen erzeugt. Die flache Perforation ist rot hervorgehoben und zeigt die begrenzte Tiefe für die Freisetzung von Stammzellen

Average 3 mm depth

microfracturing

Traditional microfracturing creates shallower channels that only reach a limited depth. These shallow perforations result in less release of stem cells from the bone marrow and therefore less effective cartilage regeneration.

Illustration der Nanofrakturierung mit NanoFx®: Tiefe Kanäle von durchschnittlich 9 mm reichen tief in das Knochengewebe und fördern eine höhere Stammzellausbeute für verbesserte Knorpelregeneration

Average 9mm depth

nanoFX® (nanofracturing)

nanoFX® creates deeper channels that reach up to 9 mm into the bone. These deeper perforations enable higher stem cell yield and promote improved regeneration of cartilage tissue, resulting in more stable and efficient healing.

BETTER

Better cartilage regeneration
through deeper, open
trabecular canals

Compared to conventional methods, nanoFX® produces deeper, 9 mm perforations with open trabecular channels. These open channels enable higher stem cell yield and more effective cartilage regeneration, while closed channels restrict healing in other methods.

Closed trabecular canals

Closed trabecular channels limit stem cell yield and hinder effective healing of cartilage defects.

Open trabecular canals

Open trabecular channels enable better stem cell yield and effectively promote cartilage regeneration.

Röntgenaufnahmen zeigen geschlossene trabekuläre Kanäle (rote Dreiecke) nach Mikrofrakturierung, was die Freisetzung von Stammzellen behindert und die Heilung von Knorpel- und Knochendefekten einschränkt

Closed channels

microfracturing

Microfracturing creates closed trabecular channels that restrict the release of stem cells and make the healing of cartilage and bone defects less effective.

Röntgenaufnahmen zeigen offene trabekuläre Kanäle (rote Dreiecke) nach Nanofrakturierung mit NanoFx®, die tief in die Spongiosa reichen und die Freisetzung von Stammzellen für eine effektive Knorpelregeneration fördern

Open channels

nanofracturing (nanoFX®)

nanoFX® creates open trabecular channels that reach deep into the spongy gland. These channels enable higher stem cell yield and promote effective cartilage regeneration.

Röntgenaufnahmen zeigen geschlossene trabekuläre Kanäle (rote Dreiecke) nach Einsatz eines K-Drahts, was den Zugang zu pluripotenten Zellen einschränkt und die Heilung von Knochen und Knorpel weniger effektiv macht

Closed channels

K-wire

The use of K-wire results in closed trabecular channels, which offer less access to pluripotent cells and therefore result in less efficient bone and cartilage healing.

Benefits of Nano FX® for standard microfracturing

Always sharp

Nano FX® guidewires always stay sharp as they are single-use instruments, allowing for more precise and effective perforations without loss of performance.

Improved access to bone marrow cells

The 9 mm deep perforations of nanoFX® reach deeper bone tissue, which results in higher stem cell yield and better regeneration.

Less subchondral bone damage

By using a 1 mm thin guidewire, nanoFX® reduces bone surface disorder, which results in less damage to the subchondral bone plate and faster healing.

More channels, more cells

The 1 mm thick nanoFX® pleuristic guidewire allows more channels to be created in the defect area, resulting in a higher number of stem cells in the joint.

Treatment methods for cartilage damage

nanoFX® compared to other processes

Balkendiagramm zeigt geeignete Behandlungsmethoden nach Defektgröße: NanoFx für kleine Defekte, HyaloFast für mittelgroße und autologe Chondrozyten-Transplantation (Spherox) für größere Defekte

Microfracturing (nanoFX®)

Suitable for smaller defects up to 2 cm²
Mobilizes stem cells from bone marrow to promote cartilage regeneration

HyaloFast®

Suitable for defect sizes of 1 to 4.5 cm²
Serves as a framework for stem cells and supports healing

More about HyaloFast®

Autologous Chondrocyte Transplantation (Spherox)

Suitable for defect sizes from 2 cm² to 10 cm²
Involves the removal and cultivation of the patient's own cartilage cells, which are then transplanted

More about Spherox

According to regulations, information is only available to doctors!

Results compared to standard microfracturing

MRT-Aufnahme drei Monate nach Mikrofrakturierung zeigt unregelmäßige Auffüllung und gestörte Knochenoberfläche (rot markierter Bereich)

3 months after surgery

microfracturing

Irregular filling with significant bone surface disorder.

MRT-Aufnahme drei Monate nach NanoFx®-Behandlung zeigt eine glatte und kontinuierliche Auffüllung ohne Störungen der Knochenoberfläche (rot markierter Bereich)

3 months after surgery

nanoFX® (nanofracturing)

Smooth, continuous filling without affecting the bone surface.

nanoFX® instrument overview

NanoFx Mehrweg-Handinstrument für Knie und Schulter, entwickelt zur Durchführung der Nanofrakturierung

5500-1020

Reusable hand instrument (knee, shoulder)

The main tool for carrying out nanofracturing

Steriler Einweg-PleuriStik-Führungsdraht (Standard und A-Curve) für die Nanofrakturierung.

Standard FURS-2101, A-Curve FURS-4101

Sterile disposable pleuristic guidewire (standard and A-curve)

The main tool for carrying out nanofracturing

Steriles Einweg-Daumenstück (Thumb Tab) zur Unterstützung bei der Nanofrakturierung

FURS-0100

Sterile disposable thumb tab thumb piece

The main tool for carrying out nanofracturing

NanoFx Mehrweg A-Curve Handinstrument für minimalinvasive Eingriffe am Sprunggelenk

5500-4010

Reusable A-Curve hand instrument (ankle joint)

The main tool for carrying out nanofracturing

nanoFX® surgical technology

The 4-step process enables minimally invasive & efficient treatment for optimal restoration of cartilage tissue.

Step 1

Insert the pleuristic guidewire

Place the tip of the Arthrosurface NanoFX pleuristic guidewire (with the thumb tab accessory) first into the proximal lumen of the hand instrument.

Schritt 1: PleuriStik-Führungsdraht mit Thumb Tab-Zubehör in das proximale Lumen des NanoFx-Handinstruments einführen

Step 2

Placement at destination

Position the distal tip of the nanoFX® handheld instrument at the desired target location.

Schritt 2: Distale Spitze des NanoFx®-Handinstruments an der Zielstelle positionieren

Step 3

Create channels

Gently hit the exposed proximal head of the pleuristic guidewire with the hammer to bring the wire in to the full depth of 9 mm.

Schritt 3: Leichtes Klopfen mit dem Hammer auf das proximale Kopfstück des PleuriStik-Führungsdrahts, um den Draht bis zur vollen Tiefe von 9 mm einzubringen

Step 4

Extraction and Repetition

Use the Thumb Tab for easy, one-handed pleuristic guidewire extraction. Place the needle approximately 2 mm away from the previous channel and repeat steps 2-4 until there are enough nanoFX® channels.